Discover the actresses who have defined comedy in Hollywood with their hilarious performances. This list celebrates the funniest and most talented women in the film industry, from iconic legends to contemporary stars. Explore their memorable roles and impact on the comedy genre, highlighting their ability to make millions laugh. It is ideal for film buffs and comedy enthusiasts looking for the best female performances. Dive into the world of the great ladies of laughter on the big screen.
Oscar winner
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Anne Hathaway is a versatile actress returning to comedy in 2026 with the anticipated sequel 'The Devil Wears Prada 2', reprising her iconic role as Andy Sachs. Her involvement in this high-profile project solidifies her as a relevant figure in contemporary comedic cinema.
Versatile across genres
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Although better known for her dramatic and action roles, Zendaya ventures into romantic comedy with 'The Drama', a film set to premiere in April 2026. This foray into a new genre with a leading role positions her as an actress to watch in the realm of comedy.
Received critical acclaim for her performances
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Ayo Edebiri has emerged as a force in comedy, known for her precision in humor and her ability to combine it with drama. Her growing recognition and multiple talents as an actress and screenwriter make her a key figure in current comedy.
Achieved stardom on Saturday Night Live
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Kristen Wiig is one of Hollywood's most influential and beloved comedians, known for her work on 'Saturday Night Live' and films like 'Bridesmaids'. Her edgy and outspoken style remains a benchmark and keeps her active in the industry.
Comedy legend
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Melissa McCarthy is a force of nature in comedy, recognized for her energy and memorable roles in films like 'Bridesmaids' and 'Pitch Perfect'. Her ability to generate laughter and her stage presence keep her as one of the most recognized comedic actresses.
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Head writer for Saturday Night Live
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Tina Fey is an eminence in comedy, with a three-decade career as an actress, screenwriter, and producer, notably in 'Saturday Night Live' and '30 Rock'. Her legacy and continued involvement in comedic projects keep her in the elite of the genre.
Makes us laugh
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Amy Poehler is a key figure in comedy, known for her work on 'Parks and Recreation' and her versatility as a screenwriter and director. Her influence in television and film comedy, often in collaboration with Tina Fey, keeps her as one of the best.
Known for work in Saturday Night Live
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Julia Louis-Dreyfus is an eminence in comedy, with an impressive career that includes multiple Emmy Awards for her roles in 'Seinfeld' and 'Veep'. Her mastery of comedic performance places her among the best actresses in the genre.
Reigning queen of romantic comedies
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Jennifer Aniston, globally famous for her role as Rachel Green in 'Friends', has maintained a successful career in film and television comedy. Her charisma and comedic talent keep her as a relevant and beloved figure in the genre.