Top role-playing games with an alchemy system

Discover the best role-playing games that incorporate deep and immersive alchemy systems. Explore worlds where potion crafting, mastery of herbalism, and experimentation with ingredients are key to your character's progression. This selection is designed for players seeking detailed crafting mechanics and the thrill of transforming basic elements into powerful elixirs. Dive into epic adventures where alchemy is not just a skill, but a fundamental pillar of gameplay. Find your next alchemical obsession and perfect the art of transmutation in these RPGs.

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  1. 1

    Pathfinder: Wrath of the Righteous (2021)

    181 Global Votes
    • Features an Alchemist class

      (+4)

    This popular CRPG offers a dedicated Alchemist class, providing a deep and varied alchemy experience through a vast arsenal of handmade potions, extracts, elixirs, and bombs. It allows for diverse playstyles.

  2. 2

    Kingdom Come: Deliverance II

    62 Global Votes
    • Features unique and specific potion recipes

      (+4)

    This recent sequel integrates a detailed and vital alchemy system as a non-combat skill, crucial for survival and progression. It emphasizes precision and ingredient freshness, making it a unique and immersive experience.

  3. 3

    The Elder Scrolls V: Skyrim

    35 Global Votes
    • Allows creation of potions and poisons

      (+3)

    Despite its age, Skyrim remains immensely popular and its robust alchemy system is consistently cited as a top example in RPGs. It encourages experimentation and allows for powerful concoctions.

  4. 4

    Alkahest (2026)

    0 Global Votes
    • Features a complex and important alchemy system

      (+4)

    As a highly anticipated Action-Adventure RPG slated for release in 2026, Alkahest positions alchemy as its central and essential gameplay system. It replaces traditional magic, offering a fresh take on the genre.

  5. 5

    Ways of Alchemy (2025)

    0 Global Votes
    • Features a unique alchemical system

      (+4)

    Released in late 2025, this indie RPG and simulation game offers a fresh perspective by focusing entirely on the life of a medieval alchemist. It combines strong RPG elements with a unique card-based simulator framework.

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  7. 6

    The Serpent Rogue (2022)

    0 Global Votes
    • Features a unique crafting system for alchemy

      (+4)

    Despite its 2022 release, The Serpent Rogue remains relevant for its unique roguelike RPG experience centered around mastering alchemy. Experimentation with crafting and brewing is key to combating corruption and altering abilities.

  8. 7

    Underrail (2015)

    0 Global Votes
    • God-tier crafting system

      (+4)

    This old-school isometric RPG is praised for its 'god-tier crafting system' that includes extensive alchemy, vital for character builds and combat strategies. Its enduring quality is confirmed by recent reviews.

  9. 8

    The Elder Scrolls III: Morrowind (2002)

    0 Global Votes
    • Alchemy allows crafting potions for temporary effects

      (+4)

    Morrowind's alchemy system is renowned for its depth and freedom, often praised for being more intricate and exploitable than later Elder Scrolls titles. It offers unparalleled player agency in crafting.

  10. 9

    Secret of Evermore (1995)

    0 Global Votes
    • Alchemy system is great

      (+4)

    This retro action RPG features a unique alchemy-as-magic system, where collected ingredients are used to cast spells. It encourages exploration and ingredient gathering for diverse alchemical effects.